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Lymphocyte populations and cytokine concentrations in pericardial fluid from a systemic lupus erythematosus patient with cardiac tamponade
  1. LUIS M VILÁ,
  2. JOSÉ R RIVERA DEL RÍO
  1. LUIS M VILÁ,
  2. ZILKA RÍOS,
  3. ELIZABETH RIVERA
  1. Department of Internal Medicine, Universidad Central del Caribe School of Medicine, Bayamón, Puerto Rico
  2. Department of Microbiology and Immunology, Universidad Central del Caribe School of Medicine, Bayamón, Puerto Rico
  1. Dr L M Vilá, Department of Internal Medicine, Division of Rheumatology, Universidad Central del Caribe School of Medicine, Call Box 60327, Bayamón, Puerto Rico 00960–6032, USA.

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Pericardial involvement is the most common cardiovascular complication in systemic lupus erythematosus (SLE).1 The clinical picture varies from subclinical pericardial effusion and classic acute pericarditis to cardiac tamponade.1 ,2Immunological studies of pericardial fluid (PF) have been limited to determination of autoantibodies, complements and immune complexes.3 ,4 To further study the pathogenic mechanisms involved in lupus pericarditis we examined the lymphocytic populations and cytokine concentration pattern in PF and peripheral blood (PB) from a SLE patient with cardiac tamponade.

We report a case of a 38 year old man with SLE diagnosed in December 1995 when he presented with polyarthritis, photosensitivity, oral ulcers, nephritis, non-hemolytic anaemia, positive ANA, increase of anti-dsDNA and hypocomplementaemia. The patient improved with corticosteroid and …

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