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Admissible evidence
  1. PETER CROFT
  1. University of Keele, School of Postgraduate Medicine, Industrial and Community Health Research Centre, Thornburrow Drive, Hartshill, Stoke on Trent ST4 7QB

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An article appeared recently in a journal for general practitioners, in which the author (a general practitioner) told the story of his own shoulder pain.1 He had had some physiotherapy that made it feel better, and then had read a meta-analysis that said that physiotherapy was of no proven benefit for shoulder pain. His shoulder pain had recurred and he had had an injection that made it feel a lot better, and then had read a meta-analysis that concluded that there was little scientific basis for injecting the shoulder. “Are we using the right sort of evidence?” he pleaded in desperation.

Musculoskeletal doctors will recognise that plea. The GP had admittedly overinterpreted the meta-analyses because each one would have ended with the observation that “there have been too few randomised controlled trials of sufficient quality on which to base a judgement of effectiveness”. This does not mean that physiotherapy or shoulder injections are useless. The absence of evidence is a very different affair to having clear evidence that an intervention does not work. Why then will so many clinicians feel sympathy with the perplexed GP?

If it moves, randomise it

The proponents of evidence-based medicine are careful to emphasise that all types of evidence are admissible in judging the most effective and efficient way to treat an individual patient.2However, the main manifestation of evidence-based medicine worldwide (the Cochrane Collaboration) gives primacy to evidence from randomised controlled trials. At a strictly scientific level this is fine: it is the closest we can come in the dirty reality of daily life to the paradigm of the laboratory experiment. By randomising we create groups of patients who do not differ in any systematic way except for the one in which we are interested (the intervention). The comparison is thus focused on the intervention, uncluttered by …

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