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Correspondence
Ankylosing spondylitis: evidence for a non-HLA-B*27 protective effect
  1. SJEF VAN DER LINDEN,
  2. DÉSIRÉE VAN DER HEIJDE
  1. Department of Medicine, Division of Rheumatology, University of Maastricht, PO Box 5800, NL-6202-AZ Maastricht, the Netherlands
  1. Professor van der Linden.

https://doi.org/10.1136/ard.57.4.263a

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    The question whether or not there is evidence for a non-HLA-B*27 protective effect is still open to debate.1-3 The likelihood of finding cases of ankylosing spondylitis (AS) depends on assumptions on the risk for HLA-B27 positive persons to develop the disease. Prevalence figures as low as 1.3% and 1.4% have been reported for population based studies in Zoetermeer (the Netherlands) and Busselton (Australia). These figures are based on populations where most people underwent pelvic radiography.4 5 Estimates based on completion of questionnaires and random sampling provide …

    Dr M A Brown.

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