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Synovial fluid concentrations of the C-propeptide of type II collagen correlate with body mass index in primary knee osteoarthritis
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  1. Tatsuo Kobayashia,
  2. Yasuo Yoshiharaa,
  3. Atsuyoshi Samuraa,
  4. Harumoto Yamadaa,
  5. Masayuki Shinmei*,a,
  6. Harald Roosb,
  7. L Stefan Lohmanderb
  1. aDepartment of Orthopaedic Surgery, National Defence Medical College, Tokorozawa, Japan , bDepartment of Orthopaedics, University Hospital, S-221 85 Lund, Sweden
  1. Dr T Kobayashi, Department of Orthopaedic Surgery, National Defence Medical College, 3-2 Namiki, Tokorozawa, Saitama, 359, Japan.

Abstract

OBJECTIVE To explore in a cross sectional study in patients with primary knee osteoarthritis (OA) the relations between body mass index (BMI), disease stage, and the concentrations of a putative joint fluid marker of type II collagen synthesis, procollagen II C-propeptide.

PATIENTS AND METHODS The study included 142 patients with knee OA (median age 68, median BMI 24.1). OA was staged radiologically. The concentrations in synovial fluid of procollagen II C-propeptide were measured by a sandwich enzyme immunoassay.

RESULTS Joint fluid concentrations of procollagen II C-propeptide were increased in knees with OA (median 3.7 ng/ml), compared with published reference values for knees in healthy adult volunteers (median 1.3 ng/ml). The concentrations of procollagen II C-propeptide were independently related to both OA stage and BMI (r s = 0.343, p < 0.0001 andr s = 0.253, p = 0.002, respectively).

CONCLUSIONS Joint fluid concentrations of this putative marker of collagen II synthesis are high in early and mid-stage OA, but decrease in end stage disease. In addition and for the first time it was shown that the concentrations in synovial fluid of procollagen II C-propeptide increase with increasing BMI in primary knee OA. The increased joint fluid values of this marker in patients with primary knee OA and a high BMI, may reflect increased rates of collagen synthesis in their joint cartilage and could relate to the previously shown increased risk for disease progression in such patients.

  • osteoarthritis
  • body mass index
  • cartilage
  • collagen synthesis
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Footnotes

  • * Dr Shinmei is deceased.

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