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Sister chromatid exchange analysis in the lymphocytes of patients with ankylosing spondylitis
  1. Sinan Sönmeza,
  2. Kazım Şenelb,
  3. Sıtkı Öztaşa,
  4. Akın Erdalb,
  5. Lale Cerrahoğlub
  1. aDepartments of Medical Genetics , band Physical Medicine and Rehabilitation , cAtatürk University Faculty of Medicine, Erzurum, Turkey
  1. Dr S Sönmez, Atatürk Universitesi Tip Fakültesi Tibbi Genetik Anabilim Dali, 25240 Erzurum, Turkey.


OBJECTIVE This study investigated whether any genomic change occurs in DNA level in ankylosing spondylitis (AS) by measuring sister chromatid exchange (SCE) frequency.

METHODS SCE frequency was detected on metaphase chromosomes obtained from peripheral blood lymphocyte cultures in 15 patients diagnosed as having AS. SCE values were also obtained from 15 healthy subjects as a control group. SCE frequencies were detected from metaphases obtained from standard blood cultures by using bromodeoxyuridine and staining by Giemsa.

RESULTS SCE frequencies of AS were statistically higher than those of the control group (p<0.005).

CONCLUSION These results suggest that genetic factors may play a more important part than realised in the aetiology of AS.

  • sister chromatid exchange
  • ankylosing spondylitis
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