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Thrombocytopenia in the antiphospholipid syndrome
  1. Maria José Cuadradoa,
  2. Fedza Mujicb,
  3. Elisa Muñozc,
  4. Munther A Khamashtab,
  5. Graham R V Hughesb
  1. aSección de Reumatologia, Hospital “Reina Sofia”, Cordoba, Spain , bLupus Arthritis Research Unit, The Rayne Institute, St Thomas’s Hospital, London , cDepartamento de Biostadistica, Facultad de Medicina, Universidad de Cordoba, Spain
  1. Dr Munther A Khamashta, Lupus Research Unit, The Rayne Institute, St Thomas’s Hospital, London SE1 7EH.


OBJECTIVE To determine the prevalence of thrombocytopenia in a group of patients suffering from the antiphospholipid syndrome (APS) and to investigate whether these patients may have any particular clinical or serological features.

METHODS Retrospective analysis. A group of 171 APS patients seen in our department were studied for the presence of thrombocytopenia. Clinical and serological features of these patients were analysed by standard methods and each of them was correlated to the presence of thrombocytopenia and compared with those found in the group without thrombocytopenia.

RESULTS Each of the patients studied had a minimum of three platelet counts during the follow up period. Forty (23.4%) were found to have thrombocytopenia; 13 with persistently low and 27 patients with intermittently low platelet counts. There were no statistically significant differences in sex, age, disease duration or diagnosis when compared with the group of APS patients without thrombocytopenia. Thrombocytopenia was associated with thrombosis in 18, with miscarriages in five, and with both of these features in 13 patients. It was the only manifestation of the APS in four patients. All patients had persistently positive tests for antiphospholipid antibodies concomitantly with the low platelet counts. No significant association was found between the presence of thrombocytopenia and clinical or serological manifestations in APS patients.

CONCLUSION This study showed a prevalence of thrombocytopenia of 23.4% in APS. These patients did not present any significant clinical or serological features that distinguish them from those patients without thrombocytopenia.

  • anticardiolipin antibodies
  • lupus anticoagulant
  • thrombosis
  • miscarriage.

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