You are here

Article Text

Article menu
Download PDFPDF
Concise reports
Treatment of severe and difficult cases of systemic lupus erythematosus with tacrolimus. A report of three cases
  1. M Duddridge,
  2. R J Powell
  1. Clinical Immunology Unit, University Hospital, Queen’s Medical Centre, Nottingham
  1. : Dr M Duddridge, Clinical Immunology Unit, F Floor West Block, University Hospital, Queen’s Medical Centre, Nottingham NG7 2UH.

Abstract

OBJECTIVES An analysis of the efficacy of tacrolimus treatment in three patients with difficult and severe systemic lupus erythematosus (SLE) whose active disease had been previously poorly controlled by cyclosporine and cyclophosphamide.

METHODS A review of patient notes.

RESULTS Two patients are well controlled after six and nine months of treatment with tacrolimus 0.06 mg/kg/day and 0.18 mg/kg/day. Previous persistent vasculitis had resolved and other features of active disease were controlled. The third patient’s vasculitis had not improved significantly after two months of treatment and tacrolimus 0.17 mg/kg/day was discontinued because of nephrotoxicity.

CONCLUSION Tacrolimus may be a useful additional immunosuppressive agent in some patients whose SLE is not well controlled by conventional treatments.

  • tacrolimus
  • systemic lupus erythematosus

https://doi.org/10.1136/ard.56.11.690

Statistics from Altmetric.com

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    View Full Text