Article Text

Download PDFPDF

Intra-articular corticosteroid injections in osteoarthritis: do they work and if so, how?
  1. Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Maryland, 10 S Pine Street, Baltimore, Maryland 21201-1192, USA

Statistics from

Intra-articular (IA) corticosteroids are recommended in several guidelines for the treatment of patients with knee osteoarthritis (OA).1 ,2 They are also widely used: a recent survey of rheumatologists in the United States suggesting that over 95% use them at least ‘sometimes’ and 53% ‘frequently’.3 Before considering mechanisms of action of IA corticsteroids we should first consider the evidence that they are effective in OA.

A recent systematic review 4 summarised evidence from five controlled studies of IA corticosteroid in patients with OA knee. Using a quality rating system (originally designed to assess methodology and reporting of NSAID studies), critical analysis showed that none of the studies achieved a score of more than 3 out of a possible 8 for design. It would not be unreasonable, therefore, to conclude that our knowledge of the efficacy of corticosteroid in OA is based on inadequate data. Table 1 summarises the five studies, and two more recent studies. Generally, they show a positive effect but one that is short lived and confounded by a powerful response to placebo (in all cases an equal volume of saline). In one study,5 for example, both placebo and corticosteroid groups showed significant decreases in pain at one week, lasting for the duration of the study (eight weeks). A more recent double blind, placebo controlled, crossover study 6found a significantly greater decrease in pain with corticosteroid than placebo at three weeks. The inability to detect an effect of corticosteroids beyond three weeks may reflect insensitivity of pain as an outcome measure, rather than a lack of corticosteroid effect.

Table 1

Controlled trials of intra-articular corticosteroids in OA (modified with permission from ref 4). All drugs given by intra-articular injection unless otherwise stated

There is, therefore, some discordance between the modest and short lived benefit over placebo seen in controlled studies and the clinical experience of most rheumatologists that some patients achieve a significant and sustained response. Is it possible to predict those subjects who will respond? One study 6 examined a range of factors including function, psychosocial and disease related features. None unequivocally predicted response at three weeks (though local tenderness did have some predictive power in unadjusted analysis). Others have reported that presence of effusion, whether detected clinically or by ability to aspirate fluid at time of injection, may predict greater benefit from corticosteroids 7 but the presence of crystals or raised synovial fluid cell count do not.5 ,8 The effect of IA corticosteroid may vary from joint to joint but data outside the knee are very limited. Anecdotally, injection at the thumb base may be of prolonged benefit9and is certainly widely recommended though there have been no controlled studies of its efficacy.

If we accept the premise that corticosteroids have a beneficial effect in at least some patients with OA, how may they work? Their speed of onset suggests a direct anti-inflammatory role and certainly this is the action that is most widely recognised. In summary, glucocorticoids act directly on nuclear steroid receptors to control rate of synthesis of mRNA and proteins. This has a number of consequences, including changes in T and B cell functions, changes in white cell traffic, alterations in levels of cytokines and enzymes, and inhibition of phospholipase A2 resulting in a reduction in proinflammatory derivatives of arachidonic acid. So is OA an inflammatory disease? Historically, the answer is no: thus OA has been used as a non-inflammatory control for diseases such as rheumatoid arthritis or even as a surrogate for normal tissue. There is, however, accumulating evidence that an inflammatory component may be present in some patients at some phases of the disease. For example, synovial histology may show pronounced synovial hyperplasia and a dense mononuclear cell infiltrate, indistinguishable from that seen in RA.10 The inflammation is focal, being most pronounced where synovium is adjacent to cartilage. Recently, expression of oncoproteins 11 and NF-κB,12 an essential transcription factor for expression of a variety of proinflammatory genes, has also been demonstrated in OA synovium. In vivo, leucocytes can be shown to migrate into OA knee joints.13 Finally, systemic markers of inflammation such as C reactive protein are increased in many patients if a sensitive assay is used and appear to predict progression.14 Serum hyaluronic acid, increased in inflammatory arthropathies such as rheumatoid arthritis, is also high in some patients with OA: production of hyaluronic acid by synovial cells in vitro is reduced by corticosteroids.15

The cause of inflammation in OA remains unclear: the role of cartilage derived macromolecules and calcium containing crystals is controversial. Once initiated, the release of wear particles may contribute to a cycle of inflammation resulting in further activation of synovium and release of cytokines.16 Though inflammation can be an important part of healing and repair, in the context of OA it is generally regarded as detrimental: in animal models, for example, the degree of inflammation correlates with the amount of cartilage loss.17 In human OA knee inflammation, as reflected by knee effusion and warmth, is associated with poor clinical and radiographic outcome as is the presence of calcium pyrophosphate crystals.18 The mechanism by which inflammation may contribute to cartilage loss is thought to be via production of inflammatory cytokines such as interleukin 1, which, in turn, result in release of degradative enzymes such as collagenases and stromelysin as well as prostaglandins and plasminogen activators.19However, it also plays an important part in the symptoms of OA: most notably by modulating pain perception.20 Some products of inflammation such as bradykinin or histamine are capable of directly stimulating primary afferent nociceptive fibres while others (prostaglandins, leukotrienes, and interleukins 1 and 6) may sensitise primary afferent nociceptives to mechanical or other stimuli. Corticosteroids, by inhibiting phospholipase A2, reduce the production of these mediators and hence reduce inflammatory pain.

Despite a reasonable theoretical basis, demonstrating an in vivo anti-inflammatory effect of IA corticosteroid in OA has, to date, been difficult. A reduction in synovial permeability, as measured by clearance of 99m-Tc labelled albumin, has been reported; the clinical response being proportional to the degree of reduction.21The thermographic index, a measure of warmth and hence inflammation, is reduced one week after corticosteroid injection.8 One problem may be definition of subgroups. The ‘osteoarthritic disorders’ are a heterogeneous group of conditions and it is probable that the role of inflammation (and hence, presumably, response to corticosteroids) varies between groups and at different time points. Moreover, OA may be a phasic condition: damage occurring in short bursts rather than in a linear progression. Bone scan appearances, for example, appear to switch on and off over time with evidence of bone activity preceding radiographic change.22 Radiographic findings indicate that many joints in patients with established OA remain stable23 and some may even improve,24suggesting that the process responsible for damage to the joint is no longer active. Equally, symptoms of OA do not necessarily remain constant: over a two year period 23% patients in one study reported an improvement in pain.18 Inflammation may play a more important part at times of accelerated joint damage: perhaps corticosteroid given at these times would be particularly beneficial.

Evidence from experimental models of OA suggest that corticosteroids, both intra-articular and systemic, may also have a disease modifying role via an effect on cartilage. In a rabbit partial meniscectomy model, for example, intra-articular triamcinolone hexacetonide given before onset of OA resulted in reduced osteophyte formation, cartilage fibrillation, and chondrocyte cloning.25 Similar findings have been reported in a guinea pig model26 and in the Pond-Nuki dog model, in which even dogs with established OA showed a beneficial effect.27 A dose dependent reduction in the cartilage proteolytic enzyme stromelysin was demonstrated, accompanied by a reduction in interleukin 1β and the oncogenes c-fos and c-myc, both of which may be important for synthesis of metalloproteinases.27 This is presumably the mechanism by which triamcinolone hexacetonide results in the observed reduction in osteophyte size and severity of cartilage lesions. Reduced metalloproteinase synthesis after corticosteroids in human OA cartilage explants has also been reported.28 It should be noted that not all animal studies have shown IA corticosteroids to be protective against development of OA29 and some actually suggest an increase in loss of cartilage proteoglycan.30 These effects seem to be less relevant for primate cartilage and reports of a Charcot-like accelerated joint destruction after corticosteroid injection in human hip OA may reflect the disease itself rather than the treatment.31

How could mechanisms of action be investigated further? Selection of subjects with features of inflammation can be attempted by clinical examination using soft tissue tenderness and joint swelling as surrogate measures of synovitis. However, presence of these features does not predict greater response to NSAIDs over paracetamol32 and the reliability of such clinical measures is uncertain. Recently, magnetic resonance imaging has been shown to be an extremely sensitive method of detecting synovial inflammation. In rheumatoid arthritis, IA corticosteroids can be shown to reduce synovial effusion volume and synovial inflammation as measured by rate of enhancement after intravenous contrast (Gd-DTPA), an effect being detectable within one day of injection and lasting for several weeks.33 Magnetic resonance imaging is also capable of detecting synovial inflammation in OA34 and thus represents a potentially useful tool. Again, using RA as a model, synovial biopsy specimens have shown that corticosteroids decrease expression of genes that play a part in articular destruction such as TIMP, collagenase, and HLA-DR35: this could also be studied in OA. Finally, biochemical markers may be useful though, to date, results have been generally disappointing. A decrease in serum keratan sulphate after a single IA corticosteroid injection in OA has been reported36 suggesting a possible reduction in catabolism of aggrecan but as corticosteroids may also reduce formation of matrix components 30 interpretation of these results is complex.

In summary, the mechanism of action of IA corticosteroids in OA is difficult to evaluate, especially when evidence for efficacy is relatively weak. Rheumatologists are likely to continue to use them either when all else fails or when we perceive there to be a moderate inflammatory component to the patient’s symptoms: in the future we may be able to refine patient selection using techniques such as magnetic resonance imaging or use of serum or synovial markers of inflammation. We should be cautious about extrapolating a protective effect of IA corticosteroids in animal models to human OA. However, if we were able to predict ‘at risk’ groups using prospective studies of subjects with early disease, we would at least be able to test the hypothesis that selective anti-inflammatory intervention may reduce progression in OA.


The author wishes to thank Paul Dieppe and Marc Hochberg for comments during manuscript preparation


Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.