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Increased serum IgE level and interleukin-4 release from cultured lymphocytes from a patient with adult onset Still's disease.
  1. K Yokoi,
  2. E Hosoi,
  3. M Nakanishi,
  4. T Goto,
  5. S Saito
  1. First Department of Internal Medicine, School of Medicine, University of Tokushima, Japan.


    OBJECTIVE--To evaluate the relationship between high serum levels of IgE and the release of interleukin-4 (IL-4) from cultured lymphocytes of a patient with adult onset Still's disease. METHODS--IL-4 concentrations in plasma and culture from inactivated peripheral blood mononuclear cells were assessed by enzyme immunoassay during febrile episodes and remission. RESULTS--A high level of IL-4 was detected by enzyme immunoassay in the peripheral blood mononuclear cells cultured from the patient. These seemed to correspond with a febrile episode and a high serum IgE concentration. CONCLUSION--Increased serum IgE concentrations during a febrile episode are rare in patients with adult onset Still's disease, but the relationship between the high levels of serum IgE and IL-4 in cultured lymphocytes may provide clues to pathogenesis of the condition.

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