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Hypersensitivity to molybdenum as a possible trigger of ANA-negative systemic lupus erythematosus.
  1. M Federmann,
  2. B Morell,
  3. G Graetz,
  4. M Wyss,
  5. P Elsner,
  6. R von Thiessen,
  7. B Wüthrich,
  8. D Grob
  1. Medizinische Abteilung, Spital Schweizerische Pflegerinnenschule, Zürich, Switzerland.


    After implantation of two metal plates a 24 year old woman developed fever of unknown origin and successively more symptoms of an ANA-negative systemic lupus erythematosus (SLE). These symptoms resolved after removal of the plates and recurred during patch testing of the metal components, which showed a reaction to molybdenum. A lymphocyte transformation test indicated a delayed-type hypersensitivity to molybdenum. Subsequent progressive flare ups of SLE appeared without molybdenum reexposure. This is the first report suggesting the existence of a hypersensitivity to molybdenum, which may act as another environmental trigger for SLE.

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