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HLA-DP does not contribute towards susceptibility to systemic lupus erythematosus.
  1. E J Davies,
  2. C J Hutchings,
  3. M C Hillarby,
  4. R P Donn,
  5. R G Cooper,
  6. E M Hay,
  7. R M Bernstein,
  8. P J Holt,
  9. D M Grennan,
  10. W E Ollier
  1. University of Manchester, Rheumatic Diseases Centre, Hope Hospital, Salford, United Kingdom.


    OBJECTIVES--To determine whether HLA-DP genes are involved in determining susceptibility to systemic lupus erythematosus (SLE). METHODS--HLA-DPA1 and DPB1 genes were amplified by PCR of DNA samples from a panel of patients with SLE and normal controls. Amplified DNA was blotted on to nylon filters and probed with sequence-specific oligonucleotide (SSO) probes. RESULTS--No DPA1 or DPB1 allele was significantly associated with SLE, or with any immunological or clinical subset of SLE. Evidence was found for only limited linkage disequilibrium between HLA-DP and HLA-DQ/DR variants, and none between HLA-DP and the TAP2 gene. CONCLUSIONS--These data indicate that HLA-DP genes do not contribute towards determining susceptibility to SLE.

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