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Yersinia associated arthritis in SHR rats: effect of the microbial status of the host.
  1. C Gripenberg-Lerche,
  2. P Toivanen
  1. Department of Medical Microbiology, Turku University, Finland.


    Following the intravenous injection of live Yersinia enterocolitica O:8, 50-69% of SHR rats developed arthritis; these rats were antibody free against all rat pathogens tested. In contrast, only 20-25% of SHR rats which had serum antibodies against Bacillus piliformis, Kilham rat virus, and Toolan H-1 virus developed arthritis. The results indicate that the microbial load of the host has a profound effect on the susceptibility to experimental arthritis.

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