Article Text

Download PDFPDF

HLA antigen familial study in complete Behçet's syndrome affecting three sisters.
  1. J L Villanueva,
  2. J Gonzalez-Dominguez,
  3. R Gonzalez-Fernandez,
  4. J L Prada,
  5. J Peña,
  6. R Solana
  1. Service of Internal Medicine, Hospital Regional Universitario Reina Sofia, Cordoba, Spain.


    Behçet's disease is a multisystemic disease affecting most organs. Although a tendency towards an association with a certain genetic type and with HLA-B51 is suspected, the incidence of several siblings with Behçet's disease in a single family is rare. A family, in which three sisters were affected with Behçet's disease, uveitis being the most severe manifestation, was studied. In this family all siblings were B51 positive. Only the female siblings, however, with a positive identical HLA phenotype: A2, A11, B51, B44, Cw6, Cw5, DR4, DRw13, DRw53, DRw52, DQw7, DQw6, developed the disease symptoms, whereas none of the male siblings was affected.

    Statistics from

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.