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Correlation of antibodies to ribosomal P protein with psychosis in patients with systemic lupus erythematosus.
  1. Y Nojima,
  2. S Minota,
  3. A Yamada,
  4. F Takaku,
  5. S Aotsuka,
  6. R Yokohari
  1. Third Department of Internal Medicine, Faculty of Medicine, Tokyo University, Japan.


    Ninety one Japanese patients with systemic lupus erythematosus (SLE) were studied to determine the clinical significance of antibodies to ribosomal P protein (anti-P). Anti-P was detected by western blotting in 38 of 91 patients (42%). Clinical symptoms of SLE were compared between patients with and without anti-P. The occurrence of lupus psychosis was significantly higher in patients with anti-P than in those without anti-P (9/38 v 1/53). No significant association was found between anti-P and other symptoms of SLE. These data strongly support the suggestion proposed by previous workers that anti-P is a marker autoantibody for the development of lupus psychosis.

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