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Antiphospholipid antibodies in homozygous sickle cell disease.
  1. K De Ceulaer,
  2. M A Khamashta,
  3. E N Harris,
  4. G R Serjeant,
  5. G R Hughes
  1. Medical Research Council Laboratories, University of the West Indies, Kingston, Jamaica.


    Serum samples from 108 unselected Jamaican patients with homozygous sickle cell disease and 116 control subjects with normal haemoglobin were screened for the presence of antiphospholipid antibodies. Slightly increased levels of IgG antiphospholipid antibodies were found in nine patients with sickle cell disease and in none of the control subjects. Serial control samples confirmed the increased levels of antiphospholipid antibodies. A comparison of the haematological and clinical features of patients with positive and negative antiphospholipid sickle cell disease did not highlight any differences between the groups.

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