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Methotrexate treatment of rheumatoid arthritis: is a fortnightly maintenance schedule enough?
  1. M Tishler,
  2. D Caspi,
  3. M Yaron
  1. Department of Rheumatology, Ichilov Hospital, Tel Aviv Sourasky Medical Center, Israel.


    In 15 patients with rheumatoid arthritis who were in clinical remission the weekly regimen of methotrexate treatment was changed to fortnightly without a change in dose. A total of 13 patients completed a 12 month trial. No change in clinical or laboratory parameters occurred. There was no change in the use of analgesics or non-steroidal anti-inflammatory drugs and the patients remained in remission. Two patients had to be withdrawn after two and four months respectively because of a flare in disease activity. It is suggested that in most patients with rheumatoid arthritis who are treated with methotrexate and whose disease activity is stable a fortnightly regimen can be permitted without affecting drug efficacy.

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