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Central nervous system systemic lupus erythematosus mimicking progressive multifocal leucoencephalopathy.
  1. B R Kaye,
  2. C M Neuwelt,
  3. S S London,
  4. S J DeArmond
  1. East Bay Rheumatology Medical Group, Oakland, CA.


    The case is reported of a patient with central nervous system systemic lupus erythematosus (SLE) with features of progressive multifocal leucoencephalopathy (PML) seen clinically and by magnetic resonance imaging. A brain biopsy sample showed microinfarcts. The use of magnetic resonance imaging and IgG synthesis rates in evaluating central nervous system lupus, the co-occurrence of SLE and PML, and the differentiation of these entities by magnetic resonance imaging and by histology are considered.

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