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A prospective study on antiribosomal P proteins in two cases of familial lupus and recurrent psychosis.
  1. R H Derksen,
  2. A P van Dam,
  3. F H Gmelig Meyling,
  4. J W Bijlsma,
  5. R J Smeenk
  1. Division of Immunopathology, Department of Internal Medicine, University Hospital Utrecht, The Netherlands.


    In two siblings with systemic lupus erythematosus (SLE), who experienced two episodes of psychosis each, a longitudinal study of autoantibodies, including antibodies to ribosomal P proteins, is described. In two of three evaluable periods of 15 weeks antedating psychosis a rise followed by a spontaneous drop in anti-P levels was recorded. In the third period antibodies to ribosomal protein P were absent. It is concluded that results with single samples are not informative, and that frequent measurement of antibodies to ribosomal protein P in patients with SLE may have limited predictive value for psychosis.

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