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Fatal aplastic anaemia and liver toxicity caused by D-penicillamine treatment of rheumatoid arthritis.
  1. B Fishel,
  2. M Tishler,
  3. D Caspi,
  4. M Yaron
  1. Department of Rheumatology, Ichilov Hospital, Tel Aviv Medical Center, Israel.


    A 65 year old woman with rheumatoid arthritis developed marrow aplasia and jaundice owing to D-penicillamine treatment. Recovery of bone marrow was ineffective, and the patient finally died despite intensive therapeutic measures. The rare coexistence of myelotoxicity and hepatotoxicity is presented and discussed.

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