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Relation between soluble interleukin 2 receptor and clinical findings in patients with systemic lupus erythematosus.
  1. Y Tokano,
  2. A Murashima,
  3. Y Takasaki,
  4. H Hashimoto,
  5. K Okumura,
  6. S Hirose
  1. Department of Internal Medicine, Juntendo University School of Medicine, Tokyo, Japan.


    The concentration of soluble interleukin 2 receptor (IL-2R) was determined in the serum of 54 patients with systemic lupus erythematosus (SLE) by an enzyme linked immunosorbent assay (ELISA) using two monoclonal antibodies with the IL-2R. Concentrations of soluble IL-2R in the serum of the patients with SLE (study group) were significantly higher than in 20 normal subjects (control group). The relation between concentrations of soluble IL-2R and clinical findings was investigated. The concentration of soluble IL-2R showed no particular relation with the clinical manifestations and did not correlate with the level of anti-DNA antibody or CH50. Significant correlation between the concentration of soluble IL-2R and disease activity did exist, however. Furthermore, the concentration of soluble IL-2R in some cases changed simultaneously with the disease activity. Thus the concentration of soluble IL-2R may serve as a new clinical indicator of disease activity in patients with SLE.

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