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Sodium aurothiomalate does not block interleukin 1 production in rabbits.
  1. Y Zurovsky,
  2. H P Laburn,
  3. D Mitchell,
  4. A Ruck
  1. Department of Physiology, University of the Witwatersrand Medical School, Johannesburg, South Africa.


    Gold salts may attenuate inflammatory processes by inhibiting interleukin 1 production. It is shown that sodium aurothiomalate does not act as an antipyretic after intravenous injection of two pyrogens into rabbits. Consequently, it cannot suppress interleukin 1 production, a conclusion confirmed by an in vitro lymphocyte activating factor assay. Chronic sodium aurothiomalate treatment, however, did depress the blood leucocyte count significantly.

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