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Anticardiolipin antibodies in patients with primary immunodeficiency diseases.
  1. D Pascual-Salcedo,
  2. M C García Rodríguez,
  3. M López Trascasa,
  4. G Fontán
  1. Department of Laboratory Medicine, Hospital la Paz, Madrid, Spain.


    The presence of antibodies to cardiolipin was determined (by an ELISA) in 143 patients with primary immunodeficiency diseases. Thirty (21%) had raised anticardiolipin antibody levels compared with only three in 98 age matched controls. The highest prevalence of this autoantibody was found in the Wiskott-Aldrich syndrome. Patients with selective IgA deficiency also showed a high prevalence of this autoantibody (32%), while patients with severe defects in antibody production showed a low prevalence or did not have such autoantibodies. This study provides further evidence of the association between autoimmune phenomena and primary immunodeficiency diseases.

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