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Intra-articular apatite deposition in mixed connective tissue disease: crystallographic and technetium scanning characteristics.
  1. C W Hutton,
  2. P J Maddison,
  3. A J Collins,
  4. J A Berriman
  1. Royal National Hospital for Rheumatic Diseases, Bath.


    An acute arthritis in a patient with mixed connective tissue disease (MCTD) was found to be associated with intra-articular deposition of carbonated hydroxyapatite crystals. A technetium hydroxymethylene diphosphonate bone scan showed intense uptake in the delayed phase scan of the affected joints. Synovial fluid analysis demonstrated uptake of the radiopharmaceutical drug directly onto the crystals.

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