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Ankylosing spondylitis without B27: no evidence for gene conversion.
  1. C T Pease,
  2. S A Ellis,
  3. A J McMichael,
  4. D A Brewerton
  1. Department of Rheumatology, Westminster Hospital, London.


    Isoelectric focusing gel electrophoresis was used to look for variant HLA molecules in five patients with HLA-B27 negative ankylosing spondylitis (AS). The isoelectric points of the HLA-A and B antigens from these patients and HLA paired controls were identical. This implies that the HLA-A and B antigens from the patients with AS and the controls are similar. Gene conversion of a nucleotide sequence from a B27 positive gene is thus unlikely to be the explanation for the existence of AS in patients who are HLA-B27 negative by alloantisera typing.

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