Article Text

Download PDFPDF

Lymphoproliferative malignancy in rheumatoid arthritis: a study of 20 cases.
  1. D P Symmons,
  2. M Ahern,
  3. P A Bacon,
  4. C F Hawkins,
  5. P L Amlot,
  6. E L Jones,
  7. P Prior,
  8. D L Scott


    A series of 20 patients with definite or classical rheumatoid arthritis who subsequently developed a lymphoproliferative malignancy are described. The mean time between the onset of the 2 diseases was 13.2 years. A wide range of types of non-Hodgkin's lymphoma and Hodgkin's disease were found; there were no unusual histological features in the lymphomas. Although many of the patients had had gold, penicillamine, and other second-line drugs, none of them had received cytotoxic drugs, and there was no evidence that therapy was a cause of their malignancies. The likely cause of the association is a predisposition to both diseases.

    Statistics from

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.