Article Text

Download PDFPDF
Metabolic responses of cartilage in experimentally induced osteoarthritis.
  1. R W Moskowitz,
  2. V M Goldberg,
  3. C J Malemud


    Serial metabolic responses in developing osteoarthritis induced in the right knees of a rabbit model of partial meniscectomy (PM) were studied. Controls were sham-operated (SH) right knees, left knees of all operated animals, nd right and left knees of a nonoperated series. Glycosaminoglycan and protein synthesis and cell replication were separately analysed utilising 35 SO4, 14C-Glycine, and 3H-thymidine, respectively. Pitting, ulceration, and osteophytes, seen only in the PM knees, increased over the 12-week period of study. 3H-thymidine and 14C-glycine incorporations by PM cartilage were increased at 3 weeks, less than nonoperated control animals at 9 weeks, and approximated to those of controls at 12 weeks. 35 SO4 incorporation by tibial osteophytes was decreased at 9 and 12 weeks. Similar isotope incorporations seen after partial meniscectomy and sham surgery represented a nonspecific response to arthrotomy. Cartilage synthetic activity did not increase in parallel with degenerative change.

    Statistics from

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.