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Clotrimazole in rheumatoid arthritis.
  1. J A Wojtulewski,
  2. P J Gow,
  3. J Walter,
  4. R Grahame,
  5. T Gibson,
  6. G S Panayi,
  7. J Mason


    Forty-seven patients with active rheumatoid arthritis took part in an 8-week controlled study in which clotrimazole was compared with a standard nonsteroidal anti-inflammatory agent, ketoprofen. Although clotrimazole was shown to be effective in the treatment of the disease and superior to ketoprofen in certain measurements, if was also responsible for a high incidence of adverse effects. Improvement with clotrimazole took place more slowly but was more sustained than with ketoprofen. A significant rise in plasma cortisol and a fall in white cell count was observed in the clotrimazole treated patients.

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