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Whole body elemental composition during drug treatment of rheumatoid arthritis: a preliminary study.
  1. A C Kennedy,
  2. K Boddy,
  3. E D Williams,
  4. A T Elliott,
  5. I Harvey,
  6. I Holloway,
  7. J K Haywood


    Thirty-two female patients with rheumatoid arthritis were divided into 3 groups and treated for 6 months with prednisolone, depot tetracosactrin, or indomethacin. Their whole body content of calcium, phosphorus, and nitrogen was measured before and after 3 and 6 months' treatment by in-vivo neutron activation analysis. No significant changes in these body elements were observed as a result of the treatments. The average amounts of calcium, phosphorus, and nitrogen were lower than normal in these patients, a finding consistent with the frequent observation of osteoporosis and muscle wasting in rheumatoid arthritis.

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