Open access

Efficacy and safety of low-dose IL-2 in the treatment of systemic lupus erythematosus: a randomised, double-blind, placebo-controlled trial
Jing He, Ruijun Zhang, Miao Shao, Xiaozhen Zhao, Miao Miao, Jiali Chen, Jiajia Liu, Xiaoying Zhang, Xia Zhang, Yuebo Jin, Yu Wang, Shilei Zhang, Lei Zhu, Alexander Jacob, Rulin Jia, Xujie You, Xue Li, Chun Li, Yunshan Zhou, Yue Yang, Hua Ye, Yanying Liu, Yin Su, Nan Shen, Jessy Alexander, Jianping Guo, Julian Ambrus, Xin Lin, Di Yu, Xiaolin Sun, Zhanguo Li

Annals of the Rheumatic Diseases Sep 2019, annrheumdis-2019-215396; DOI: 10.1136/annrheumdis-2019-215396
Evidence that tissue resident human enthesis γδT-cells can produce IL-17A independently of IL-23R transcript expression
Richard James Cuthbert, Charlie Bridgewood, Abdulla Watad, Evangelos M Fragkakis, Robert Dunsmuir, Peter Loughenbury, Almas Khan, Peter A Millner, Adam Davison, Helena Marzo-Ortega, Darren Newton, Dennis G McGonagle

Annals of the Rheumatic Diseases Sep 2019, annrheumdis-2019-215210; DOI: 10.1136/annrheumdis-2019-215210
Efficacy and safety of peficitinib (ASP015K) in patients with rheumatoid arthritis and an inadequate response to methotrexate: results of a phase III randomised, double-blind, placebo-controlled trial (RAJ4) in Japan
Tsutomu Takeuchi, Yoshiya Tanaka, Sakae Tanaka, Atsushi Kawakami, Manabu Iwasaki, Kou Katayama, Mitsuhiro Rokuda, Hiroyuki Izutsu, Satoshi Ushijima, Yuichiro Kaneko, Teruaki Shiomi, Emi Yamada, Désirée van der Heijde

Annals of the Rheumatic Diseases Oct 2019, 78 (10) 1305-1319; DOI: 10.1136/annrheumdis-2019-215164
Efficacy and safety of peficitinib (ASP015K) in patients with rheumatoid arthritis and an inadequate response to conventional DMARDs: a randomised, double-blind, placebo-controlled phase III trial (RAJ3)
Yoshiya Tanaka, Tsutomu Takeuchi, Sakae Tanaka, Atsushi Kawakami, Manabu Iwasaki, Yeong Wook Song, Yi-Hsing Chen, James Cheng-Chung Wei, Sang-Heon Lee, Mitsuhiro Rokuda, Hiroyuki Izutsu, Satoshi Ushijima, Yuichiro Kaneko, Rio Akazawa, Teruaki Shiomi, Emi Yamada

Annals of the Rheumatic Diseases Oct 2019, 78 (10) 1320-1332; DOI: 10.1136/annrheumdis-2019-215163
Non-response to rituximab therapy in rheumatoid arthritis is associated with incomplete disruption of the B cell receptor repertoire
Sabrina Pollastro, Paul L Klarenbeek, Marieke E Doorenspleet, Barbera D C van Schaik, Rebecca E E Esveldt, Rogier M Thurlings, Maria J H Boumans, Danielle M Gerlag, Paul P Tak, Koen Vos, Frank Baas, Antoine H C van Kampen, Niek de Vries

Annals of the Rheumatic Diseases Oct 2019, 78 (10) 1339-1345; DOI: 10.1136/annrheumdis-2018-214898
Multi-dimensional analysis identified rheumatoid arthritis-driving pathway in human T cell
Masaru Takeshita, Katsuya Suzuki, Yasushi Kondo, Rimpei Morita, Yuumi Okuzono, Keiko Koga, Yoshiaki Kassai, Kanae Gamo, Maiko Takiguchi, Rina Kurisu, Hideyuki Mototani, Yukihiko Ebisuno, Akihiko Yoshimura, Tsutomu Takeuchi

Annals of the Rheumatic Diseases Oct 2019, 78 (10) 1346-1356; DOI: 10.1136/annrheumdis-2018-214885
Genetic variations in A20 DUB domain provide a genetic link to citrullination and neutrophil extracellular traps in systemic lupus erythematosus
Lina Odqvist, Zala Jevnikar, Rebecca Riise, Lisa Öberg, Magdalena Rhedin, Dag Leonard, Linda Yrlid, Sonya Jackson, Johan Mattsson, Sambit Nanda, Philip Cohen, Axel Knebel, Simon Arthur, Kristofer Thörn, Elisabet Svenungsson, Andreas Jönsen, Iva Gunnarsson, Karolina Tandre, Andrei Alexsson, Alf Kastbom, Solbritt Rantapää-Dahlqvist, Maija-Leena Eloranta, Ann-Christine Syvänen, Anders Bengtsson, Patrik Johansson, Johanna K Sandling, Christopher Sjöwall, Lars Rönnblom, Barry Collins, Outi Vaarala

Annals of the Rheumatic Diseases Oct 2019, 78 (10) 1363-1370; DOI: 10.1136/annrheumdis-2019-215434
Genome-wide association study revealed novel loci which aggravate asymptomatic hyperuricaemia into gout
Yusuke Kawamura, Hirofumi Nakaoka, Akiyoshi Nakayama, Yukinori Okada, Ken Yamamoto, Toshihide Higashino, Masayuki Sakiyama, Toru Shimizu, Hiroshi Ooyama, Keiko Ooyama, Mitsuo Nagase, Yuji Hidaka, Yuko Shirahama, Kazuyoshi Hosomichi, Yuichiro Nishida, Ippei Shimoshikiryo, Asahi Hishida, Sakurako Katsuura-Kamano, Seiko Shimizu, Makoto Kawaguchi, Hirokazu Uemura, Rie Ibusuki, Megumi Hara, Mariko Naito, Mikiya Takao, Mayuko Nakajima, Satoko Iwasawa, Hiroshi Nakashima, Keizo Ohnaka, Takahiro Nakamura, Blanka Stiburkova, Tony R Merriman, Masahiro Nakatochi, Sahoko Ichihara, Mitsuhiro Yokota, Tappei Takada, Tatsuya Saitoh, Yoichiro Kamatani, Atsushi Takahashi, Kokichi Arisawa, Toshiro Takezaki, Keitaro Tanaka, Kenji Wakai, Michiaki Kubo, Tatsuo Hosoya, Kimiyoshi Ichida, Ituro Inoue, Nariyoshi Shinomiya, Hirotaka Matsuo

Annals of the Rheumatic Diseases Oct 2019, 78 (10) 1430-1437; DOI: 10.1136/annrheumdis-2019-215521
A WHO Reference Reagent for lupus (anti-dsDNA) antibodies: international collaborative study to evaluate a candidate preparation
Bernard J Fox, Jason Hockley, Peter Rigsby, Carl Dolman, Pier Luigi Meroni, Johan Rönnelid

Annals of the Rheumatic Diseases Aug 2019, annrheumdis-2019-215845; DOI: 10.1136/annrheumdis-2019-215845
Anticitrullinated protein antibodies facilitate migration of synovial tissue-derived fibroblasts
Meng Sun, Bence Rethi, Akilan Krishnamurthy, Vijay Joshua, Alexandra Circiumaru, Aase Haj Hensvold, Elena Ossipova, Caroline Grönwall, Yanying Liu, Marianne Engstrom, Sergiu Bogdan Catrina, Johanna Steen, Vivianne Malmstrom, Lars Klareskog, Camilla Svensson, Caroline Ospelt, Heidi Wähämaa, Anca Irinel Catrina

Annals of the Rheumatic Diseases Sep 2019, annrheumdis-2018-214967; DOI: 10.1136/annrheumdis-2018-214967

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