CLINICAL

Pan PPAR agonist IVA337 is effective in prevention and treatment of experimental skin fibrosis
Nadira Ruzehaji, Camelia Frantz, Matthieu Ponsoye, Jerome Avouac, Sonia Pezet, Thomas Guilbert, Jean-Michel Luccarini, Pierre Broqua, Jean-Louis Junien, Yannick Allanore

Annals of the Rheumatic Diseases Dec 2016, 75 (12) 2175-2183; DOI: 10.1136/annrheumdis-2015-208029
Among human macrophages polarised to different phenotypes, the M-CSF-oriented cells present the highest pro-inflammatory response to the rheumatoid arthritis-specific immune complexes containing ACPA
Cyril Clavel, Laurie Ceccato, Florence Anquetil, Guy Serre, Mireille Sebbag

Annals of the Rheumatic Diseases Dec 2016, 75 (12) 2184-2191; DOI: 10.1136/annrheumdis-2015-208887
Complex disease=complex trial? Lessons from a successful trial of anti-IFNα in SLE
Ronald van Vollenhoven

Annals of the Rheumatic Diseases Nov 2016, 75 (11) 1899-1901; DOI: 10.1136/annrheumdis-2016-209345
Sifalimumab, an anti-interferon-α monoclonal antibody, in moderate to severe systemic lupus erythematosus: a randomised, double-blind, placebo-controlled study
Munther Khamashta, Joan T Merrill, Victoria P Werth, Richard Furie, Kenneth Kalunian, Gabor G Illei, Jorn Drappa, Liangwei Wang, Warren Greth

Annals of the Rheumatic Diseases Nov 2016, 75 (11) 1909-1916; DOI: 10.1136/annrheumdis-2015-208562
Comparison of adding tocilizumab to methotrexate with switching to tocilizumab in patients with rheumatoid arthritis with inadequate response to methotrexate: 52-week results from a prospective, randomised, controlled study (SURPRISE study)
Yuko Kaneko, Tatsuya Atsumi, Yoshiya Tanaka, Masayuki Inoo, Hitomi Kobayashi-Haraoka, Koichi Amano, Masayuki Miyata, Yohko Murakawa, Hidekata Yasuoka, Shintaro Hirata, Hayato Nagasawa, Eiichi Tanaka, Nobuyuki Miyasaka, Hisashi Yamanaka, Kazuhiko Yamamoto, Tsutomu Takeuchi

Annals of the Rheumatic Diseases Nov 2016, 75 (11) 1917-1923; DOI: 10.1136/annrheumdis-2015-208426
Anticitrullinated protein antibodies and rheumatoid factor are associated with increased mortality but with different causes of death in patients with rheumatoid arthritis: a longitudinal study in three European cohorts
S Ajeganova, J H Humphreys, M K Verheul, H W van Steenbergen, J A B van Nies, I Hafström, B Svensson, T W J Huizinga, L A Trouw, S M M Verstappen, A H M van der Helm-van Mil

Annals of the Rheumatic Diseases Nov 2016, 75 (11) 1924-1932; DOI: 10.1136/annrheumdis-2015-208579
Towards personalised treatment in primary Sjögren's syndrome: baseline parotid histopathology predicts responsiveness to rituximab treatment
Konstantina Delli, Erlin A Haacke, Frans G M Kroese, Rodney P Pollard, Stephan Ihrler, Bert van der Vegt, Arjan Vissink, Hendrika Bootsma, Frederik K L Spijkervet

Annals of the Rheumatic Diseases Nov 2016, 75 (11) 1933-1938; DOI: 10.1136/annrheumdis-2015-208304
Disease activity-guided dose optimisation of adalimumab and etanercept is a cost-effective strategy compared with non-tapering tight control rheumatoid arthritis care: analyses of the DRESS study
Wietske Kievit, Noortje van Herwaarden, Frank HJ van den Hoogen, Ronald F van Vollenhoven, Johannes WJ Bijlsma, Bart JF van den Bemt, Aatke van der Maas, Alfons A den Broeder

Annals of the Rheumatic Diseases Nov 2016, 75 (11) 1939-1944; DOI: 10.1136/annrheumdis-2015-208317
Development of the ClinESSDAI: a clinical score without biological domain. A tool for biological studies
Raphaèle Seror, Petra Meiners, Gabriel Baron, Hendrika Bootsma, Simon J Bowman, Claudio Vitali, Jacques-Eric Gottenberg, Elke Theander, Athanasios Tzioufas, Salvatore De Vita, Manel Ramos-Casals, Thomas Dörner, Luca Quartuccio, Philippe Ravaud, Xavier Mariette

Annals of the Rheumatic Diseases Nov 2016, 75 (11) 1945-1950; DOI: 10.1136/annrheumdis-2015-208504
Spatial distribution of syndesmophytes along the vertebral rim in ankylosing spondylitis: preferential involvement of the posterolateral rim
Sovira Tan, Abhijit Dasgupta, Jianhua Yao, John A Flynn, Lawrence Yao, Michael M Ward

Annals of the Rheumatic Diseases Nov 2016, 75 (11) 1951-1957; DOI: 10.1136/annrheumdis-2015-208802

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