CLINICAL

Increased prevalence and severity of radiographic hand osteoarthritis in patients with HIV-1 infection associated with metabolic syndrome: data from the cross-sectional METAFIB-OA study
Anne-Laurence Tomi, Jérémie Sellam, Karine Lacombe, Soraya Fellahi, Manuela Sebire, Caroline Rey-Jouvin, Anne Miquel, Jean-Philippe Bastard, Emmanuel Maheu, Ida K Haugen, David T Felson, Jacqueline Capeau, Pierre-Marie Girard, Francis Berenbaum, Jean-Luc Meynard

Annals of the Rheumatic Diseases Dec 2016, 75 (12) 2101-2107; DOI: 10.1136/annrheumdis-2016-209262
Ultrasonographic evaluation in psoriatic arthritis is of major importance in evaluating disease activity
Brigitte Michelsen, Andreas P Diamantopoulos, Hilde B Hammer, Dag M Soldal, Arthur Kavanaugh, Glenn Haugeberg

Annals of the Rheumatic Diseases Dec 2016, 75 (12) 2108-2113; DOI: 10.1136/annrheumdis-2015-208806
High disease activity according to the Ankylosing Spondylitis Disease Activity Score is associated with accelerated radiographic spinal progression in patients with early axial spondyloarthritis: results from the GErman SPondyloarthritis Inception Cohort
Denis Poddubnyy, Mikhail Protopopov, Hildrun Haibel, Jürgen Braun, Martin Rudwaleit, Joachim Sieper

Annals of the Rheumatic Diseases Dec 2016, 75 (12) 2114-2118; DOI: 10.1136/annrheumdis-2016-209209
Tapering conventional synthetic DMARDs in patients with early arthritis in sustained remission: 2-year follow-up of the tREACH trial
T M Kuijper, J J Luime, P H P de Jong, A H Gerards, D van Zeben, I Tchetverikov, P B J de Sonnaville, M V van Krugten, B A Grillet, J M W Hazes, A E A M Weel

Annals of the Rheumatic Diseases Dec 2016, 75 (12) 2119-2123; DOI: 10.1136/annrheumdis-2016-209272
IL-7 primes IL-17 in mucosal-associated invariant T (MAIT) cells, which contribute to the Th17-axis in ankylosing spondylitis
Eric Gracey, Zoya Qaiyum, Ibrahim Almaghlouth, Daeria Lawson, Susan Karki, Naga Avvaru, Zhenbo Zhang, Yuchen Yao, Vidya Ranganathan, Yuriy Baglaenko, Robert D Inman

Annals of the Rheumatic Diseases Dec 2016, 75 (12) 2124-2132; DOI: 10.1136/annrheumdis-2015-208902
PKCδ null mutations in a mouse model of osteoarthritis alter osteoarthritic pain independently of joint pathology by augmenting NGF/TrkA-induced axonal outgrowth
Ranjan Kc, Xin Li, Jeffrey S Kroin, Zhiqiang Liu, Di Chen, Guozhi Xiao, Brett Levine, Jinyuan Li, John L Hamilton, Andre J van Wijnen, Margaret Piel, Daniel A Shelly, Dovrat Brass, Ela Kolb, Hee-Jeong Im

Annals of the Rheumatic Diseases Dec 2016, 75 (12) 2133-2141; DOI: 10.1136/annrheumdis-2015-208444
Treatment with abatacept prevents experimental dermal fibrosis and induces regression of established inflammation-driven fibrosis
Matthieu Ponsoye, Camelia Frantz, Nadira Ruzehaji, Carole Nicco, Muriel Elhai, Barbara Ruiz, Anne Cauvet, Sonia Pezet, Marie Laure Brandely, Frédéric Batteux, Yannick Allanore, Jérôme Avouac

Annals of the Rheumatic Diseases Dec 2016, 75 (12) 2142-2149; DOI: 10.1136/annrheumdis-2015-208213
An ankylosing spondylitis-associated genetic variant in the IL23R-IL12RB2 intergenic region modulates enhancer activity and is associated with increased Th1-cell differentiation
Amity R Roberts, Matteo Vecellio, Liye Chen, Anna Ridley, Adrian Cortes, Julian C Knight, Paul Bowness, Carla J Cohen, B Paul Wordsworth

Annals of the Rheumatic Diseases Dec 2016, 75 (12) 2150-2156; DOI: 10.1136/annrheumdis-2015-208640
Methotrexate selectively targets human proinflammatory macrophages through a thymidylate synthase/p53 axis
Cristina Municio, Blanca Soler Palacios, Lizbeth Estrada-Capetillo, Alberto Benguria, Ana Dopazo, Elena García-Lorenzo, Salvador Fernández-Arroyo, Jorge Joven, María Eugenia Miranda-Carús, Isidoro González-Álvaro, Amaya Puig-Kröger

Annals of the Rheumatic Diseases Dec 2016, 75 (12) 2157-2165; DOI: 10.1136/annrheumdis-2015-208736
PPARβ/δ directs the therapeutic potential of mesenchymal stem cells in arthritis
P Luz-Crawford, N Ipseiz, G Espinosa-Carrasco, A Caicedo, G Tejedor, K Toupet, J Loriau, C Scholtysek, C Stoll, M Khoury, D Noël, C Jorgensen, G Krönke, F Djouad

Annals of the Rheumatic Diseases Dec 2016, 75 (12) 2166-2174; DOI: 10.1136/annrheumdis-2015-208696

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