Abstract
Objective
To determine levels of serum soluble OX40 (also termed CD134, a member of the tumor necrosis factor receptor superfamily) and their clinical associations in patients with systemic sclerosis (SSc).
Methods
Serum soluble OX40 levels were examined by ELISA in 53 patients with SSc, 15 patients with systemic lupus erythematosus (SLE), and 32 healthy individuals.
Results
OX40 levels were significantly elevated in SSc patients (125.7 ± 5.7 pg/ml) compared to patients with SLE (80.7 ± 1.7 pg/ml; p < 0.005) and controls (88.2 ± 3.0 pg/ml; p < 0.0001). Elevated OX40 levels were found to be associated with disease duration of less than 2 years (p < 0.05).
Conclusion
Our results suggest that serum soluble OX40 levels correlate with the early-onset of SSc disease.
Key Indexing Terms:Footnotes
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K. Komura, MD, PhD, Assistant Professor; A. Yoshizaki, MD; Y. Iwata, MD; F. Ogawa, MD, PhD, Assistant Professor; K. Shimizu, MD, PhD, Associate Professor; S. Sato, MD, PhD, Professor, Chairman, Department of Dermatology, Nagasaki University Graduate School of Biomedical Sciences; M. Kodera, MD, PhD; T. Wayaku, MD, PhD; T. Yukami, MD, PhD; M. Murata, MD; M. Hasegawa, MD, PhD, Assistant Professor; M. Fujimoto, MD, Associate Professor; K. Takehara, MD, Professor, Department of Dermatology, Kanazawa University Graduate School of Medical Science.
- Accepted for publication July 7, 2008.