Shear stress is a fundamental determinant of vascular homeostasis, regulating vascular
remodelling, cardiac development and atherogenesis, but the mechanisms of transduction …

Soluble factors from serum such as lysophosphatidic acid (LPA) are thought to activate the
small GTP-binding protein Rho based on their ability to induce actin stress fibers and focal …

Translocation of the small GTP-binding protein Rac1 to the cell plasma membrane is
essential for activating downstream effectors and requires integrin-mediated adhesion of …

Focal adhesion kinase (FAK) is activated and localized at focal adhesions upon cell
adhesion to extracellular matrices. Cells lacking FAK show increased focal adhesion …

Growth of normal cells is anchorage dependent because signalling through multiple
pathways including Erk, phosphatidylinositol-3-OH kinase (PI (3) K) and Rac requires …

Hemodynamic shear stress is a fundamental determinant of vascular remodeling and
atherogenesis. Changes in focal adhesions, cytoskeletal organization and gene expression …

The proper function of Rho GTPases requires precise spatial and temporal regulation of
effector interactions. Integrin-mediated cell adhesion modulates the interaction of GTP-Rac …

Disruption of autophagy—a key homeostatic process in which cytosolic components are
degraded and recycled through lysosomes—can cause neurodegeneration in tissue culture …

The α4 integrins are indispensable for embryogenesis, haematopoiesis and immune
responses,, possibly because α4 regulates cellular functions differently from other integrins …

TLRs are an evolutionarily conserved family of cell membrane proteins believed to play a
significant role in innate immunity and the response to tissue injury, including that induced …