Based on the fact that aging is associated with a reciprocal decrease of osteogenesis and
an increase of adipogenesis in bone marrow and that osteoblasts and adipocytes share a …

This study aimed to estimate the prevalence of locomotive syndrome, sarcopenia, and frailty
and clarify their co-existence in a population-based cohort. The third survey of Research on …

Musculoskeletal diseases, especially osteoarthritis (OA) and osteoporosis (OP), impair
activities of daily life (ADL) and quality of life (QOL) in the elderly. Although preventive …

Chondrocyte hypertrophy followed by cartilage matrix degradation and vascular invasion,
characterized by expression of type X collagen (COL10A1), matrix metalloproteinase-13 …

Study Design. A retrospective study of the long-term results from double-door laminoplasty
(Kurokawa's method) for patients with myelopathy caused by ossification of the posterior …

Since interaction between bone and lipid metabolism has been suggested, this study
investigated the regulation of bone metabolism by adiponectin, a representative adipokine …

Since the proportion of the ageing population in Japan is increasing, a comprehensive and
evidencebased strategy is urgently required for the prevention of musculoskeletal diseases …

Background: Glucose intolerance is frequently found in patients with ossification of the
posterior longitudinal ligament of the spine. This study was undertaken to examine the …

Insulin receptor substrates (IRS-1 and IRS-2) are essential for intracellular signaling by
insulin and insulin-like growth factor-I (IGF-I), anabolic regulators of bone metabolism …

Background We aimed to clarify the association between new indices in a locomotive
syndrome risk test and decline in mobility. Methods In the third survey of the Research on …