Urate is a cause of gout, kidney stones, and acute kidney injury from tumor lysis syndrome,
but its relationship to kidney disease, cardiovascular disease, and diabetes remains …

Objective Gout is the most common cause of inflammatory arthritis in men, but has not
previously been included in Global Burden of Disease (GBD) studies. As part of the GBD …

A central aspect of the pathogenesis of gout is elevated urate concentrations, which lead to
the formation of monosodium urate crystals. The clinical features of gout result from an …

Background Quantification of the disease burden caused by different risks informs
prevention by providing an account of health loss different to that provided by a disease-by …

Background In 2010, overweight and obesity were estimated to cause 3· 4 million deaths, 3·
9% of years of life lost, and 3· 8% of disability-adjusted life-years (DALYs) worldwide. The …

Background Reliable and timely information on the leading causes of death in populations,
and how these are changing, is a crucial input into health policy debates. In the Global …

Rationale: Abdominal aortic aneurysm (AAA) is a complex disease with both genetic and
environmental risk factors. Together, 6 previously identified risk loci only explain a small …

Objective To systematically test dietary components for association with serum urate levels
and to evaluate the relative contributions of estimates of diet pattern and inherited genetic …

Gout results from elevated urate concentrations in the blood (hyperuricaemia). When super-
saturation of urate is reached, monosodium urate crystals form within the joint. In some …

Objective. Elevated levels of IL-17A have been detected in the inflamed synovium of RA
patients, and murine arthritis models deficient in IL17A have shown reduced inflammation …