Fractalkine is a CX3C chemokine that exists in both membrane-bound and soluble forms.
Interaction between fractalkine and its unique receptor (CX3CR1) induces cell adhesion …

Rheumatoid arthritis (RA) is characterized by the accumulation of CD4+ memory T cells in
the inflamed synovium. To address the mechanism, we analyzed chemokine receptor …

Interaction of ICOS with its ligand is essential for germinal center formation, T cell immune
responses, and development of autoimmune diseases. Human ICOS deficiency has been …

Objective. To compare tumor necrosis factor-α (TNF-α) inhibitors to nonbiological disease-
modifying antirheumatic drugs (DMARD) for the risk of serious infection in Japanese patients …

Objective Rheumatoid arthritis (RA) is a chronic inflammatory disease associated with
massive T cell infiltration into the synovium. The accumulated T cells express type 1 …

Rheumatoid arthritis (RA) is characterized by proliferation of synoviocytes that produce
inflammatory cytokines and chemokines. The expressed chemokines are thought to be …

Macrophages that accumulate in the synovium of rheumatoid arthritis patients play an
important role in the pathogenesis of this inflammatory disease. However, the mechanism by …

Introduction Chemerin is a chemotactic agonist identified as a ligand for ChemR23 that is
expressed on macrophages and dendritic cells (DCs). In this study, we analyzed the …

Objective Rheumatoid arthritis (RA) is characterized by chronic inflammation of multiple
joints. Large numbers of T cells, which produce type 1 cytokines, infiltrate into RA synovium …

Stromal cell-derived factor (SDF)-1 is a chemoattractant for T cells, precursor B cells,
monocytes, and neutrophils. SDF-1α was also found to up-regulate expression of early …