Empiric probiotics are commonly consumed by healthy individuals as means of life quality
improvement and disease prevention. However, evidence of probiotic gut mucosal …

Objectives To validate the previously proposed classification criteria for Henoch–Schönlein
purpura (HSP), childhood polyarteritis nodosa (c-PAN), c-Wegener granulomatosis (c-WG) …

Background Interleukin-1 is pivotal in the pathogenesis of systemic juvenile idiopathic
arthritis (JIA). We assessed the efficacy and safety of canakinumab, a selective, fully human …

Probiotics are widely prescribed for prevention of antibiotics-associated dysbiosis and
related adverse effects. However, probiotic impact on post-antibiotic reconstitution of the gut …

Non-nutritive sweeteners (NNS) are commonly integrated into human diet and presumed to
be inert; however, animal studies suggest that they may impact the microbiome and …

Amyotrophic lateral sclerosis (ALS) is a complex neurodegenerative disorder, in which the
clinical manifestations may be influenced by genetic and unknown environmental factors …

FMF is widely distributed in populations inhabiting the Mediterranean basin. It is mainly
attributed to five founder mutations (M680I, M694V, M694I, V726A, E148Q) in the MEFV …

Objective The clinical profile in familial Mediterranean fever (FMF), including its major
manifestation, amyloidosis, is influenced by MEFV allelic heterogeneity and other genetic …

OBJECTIVES: Based on the fact that Henoch-Schönlein purpura (HSP) occurs in
approximately 5% of persons with familial Mediterranean fever (FMF), we assessed the …

Objectives. The aims of this study were to describe the clinical features of periodic fever,
aphthous stomatitis, pharyngitis and cervical adenitis (PFAPA) and identify distinct …