In the last decades, autoimmune diseases have experienced a dramatic increase in Western
countries. The involvement of environmental factors is strongly suspected to explain this rise …

Abstract Background The Hygiene Hypothesis (HH) attributes the dramatic increase in
autoimmune and allergic diseases observed in recent decades in Western countries to the …

The relapse rate in antiphospholipid syndrome (APS) remains high, ie around 20%–21% at
5 years in thrombotic APS and 20–28% in obstetrical APS [2, 3]. Hydroxychloroquine (HCQ) …

Background Primary immunodeficiencies (PIDs) are inherited diseases associated with a
considerable increase in susceptibility to infections. It is known that PIDs can also …

Background There is uncertainty about the impact of severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) infection in individuals with rare inborn errors of immunity (IEI) …

Pyrin responds to pathogen signals and loss of cellular homeostasis by forming an
inflammasome complex that drives the cleavage and secretion of interleukin-1β (IL-1β) …

Objectives To assess the efficacy and the safety of biologics in a cohort of patients with
relapsing polychondritis (RP). Methods We conducted a French multicentre retrospective …

Midostaurin in Advanced Systemic Mastocytosis Page 1 correspondence n engl j med 374;26
nejm.org June 30, 2016 mias and the prevention of sudden cardiac death: a report of the …

Although splenectomy is still considered the most effective curative treatment for immune
thrombocytopenia (ITP), its use has significantly declined in the last decade, especially since …

Unsurprisingly, most of the genetic diagnoses were obtained in the last 10 years (see the
Methods section and Fig E1 in this article's Online Repository at www. jacionline. org). The …