HLA-B27
P Bowness - Annual review of immunology, 2015 - annualreviews.org
Possession of the human leukocyte antigen (HLA) class I molecule B27 is strongly
associated with ankylosing spondylitis (AS), but the pathogenic role of HLA-B27 is unknown …
associated with ankylosing spondylitis (AS), but the pathogenic role of HLA-B27 is unknown …
Hereditary C1q deficiency and systemic lupus erythematosus
P Bowness, KA Davies, PJ Norsworthy… - … Journal of Medicine, 1994 - academic.oup.com
We describe a 27-year-old woman with systemic lupus erythematosus, C1q deficiency and
cytomega-lovirus retinitis. She suffered from severe SLE, with cutaneous and CNS …
cytomega-lovirus retinitis. She suffered from severe SLE, with cutaneous and CNS …
Progress in our understanding of the pathogenesis of ankylosing spondylitis
D Simone, MH Al Mossawi, P Bowness - Rheumatology, 2018 - academic.oup.com
AS is a common rheumatic condition characterized by inflammation and new bone
formation. The pathogenesis of AS is likely multifactorial and has not been fully elucidated to …
formation. The pathogenesis of AS is likely multifactorial and has not been fully elucidated to …
Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility
…, A Morgan, H Marzo-Ortega, P Bowness… - Nature …, 2011 - nature.com
Ankylosing spondylitis is a common form of inflammatory arthritis predominantly affecting the
spine and pelvis that occurs in approximately 5 out of 1,000 adults of European descent …
spine and pelvis that occurs in approximately 5 out of 1,000 adults of European descent …
Identification of multiple risk variants for ankylosing spondylitis through high-density genotyping of immune-related loci
…, P Bowness… - Nature …, 2013 - nature.com
Ankylosing spondylitis is a common, highly heritable inflammatory arthritis affecting primarily
the spine and pelvis. In addition to HLA-B* 27 alleles, 12 loci have previously been identified …
the spine and pelvis. In addition to HLA-B* 27 alleles, 12 loci have previously been identified …
[PDF][PDF] A blood atlas of COVID-19 defines hallmarks of disease severity and specificity
Treatment of severe COVID-19 is currently limited by clinical heterogeneity and incomplete
description of specific immune biomarkers. We present here a comprehensive multi-omic …
description of specific immune biomarkers. We present here a comprehensive multi-omic …
[HTML][HTML] An immunodominant NP105–113-B*07:02 cytotoxic T cell response controls viral replication and is associated with less severe COVID-19 disease
…, GL Smith, JA McKeating, BP Fairfax, P Bowness… - Nature …, 2022 - nature.com
Abstract NP105–113-B* 07: 02-specific CD8+ T cell responses are considered among the
most dominant in SARS-CoV-2-infected individuals. We found strong association of this …
most dominant in SARS-CoV-2-infected individuals. We found strong association of this …
Analysis of CD161 expression on human CD8+ T cells defines a distinct functional subset with tissue-homing properties
…, YH Oo, S Kollnberger, P Bowness… - Proceedings of the …, 2010 - National Acad Sciences
CD8+ T lymphocytes play a key role in host defense, in particular against important
persistent viruses, although the critical functional properties of such cells in tissue are not …
persistent viruses, although the critical functional properties of such cells in tissue are not …
CD56bright human NK cells differentiate into CD56dim cells: role of contact with peripheral fibroblasts
…, A McMichael, T Enver, P Bowness - The Journal of …, 2007 - journals.aai.org
Human NK cells are divided into CD56 bright CD16− cells and CD56 dim CD16+ cells. We
tested the hypothesis that CD56 bright NK cells can differentiate into CD56 dim cells by …
tested the hypothesis that CD56 bright NK cells can differentiate into CD56 dim cells by …
Cutting edge: HLA-B27 can form a novel β2-microglobulin-free heavy chain homodimer structure
…, AJ McMichael, P Bowness - The Journal of …, 1999 - journals.aai.org
HLA-B27 has a striking association with inflammatory arthritis. We show that free HLA-B27
heavy chains can form a disulfide-bonded homodimer, dependent on residue Cys 67 in their …
heavy chains can form a disulfide-bonded homodimer, dependent on residue Cys 67 in their …