The ability to sustain unscheduled proliferation is a hallmark of cancer. The normal process
of cell division occurs via the cell cycle, a series of highly regulated steps that are …

Soft tissue and bone sarcomas are malignancies of mesenchymal origin, and more than 50
subtypes are defined. For most sarcomas, locally advanced or unresectable disease is still …

Purpose: This phase I study assessed the safety, pharmacokinetics (PKs), and efficacy of
MIW815 (ADU-S100), a novel synthetic cyclic dinucleotide that activates the stimulator of IFN …

Leiomyosarcoma is an aggressive mesenchymal malignancy and represents one of the
most common subtypes of soft tissue sarcomas. It is characterized by significant disease …

Melanoma brain metastasis (MBM) frequently occurs in patients with advanced melanoma;
yet, our understanding of the underlying salient biology is rudimentary. Here, we performed …

Programming complex embedded systems involves reasoning through intricate system
interactions along lengthy paths between sensors, actuators, and control processors. This is …

Open scholarship has transformed research, and introduced a host of new terms in the
lexicon of researchers. The 'Framework for Open and Reproducible Research …

Background: The STING pathway has been implicated in antitumor immunity and response
to immune checkpoint inhibitors. Intratumoral (IT) administration of MK-1454, a cyclic …

Exosomes are nanovesicles that are released from cells as a mechanism of cell-free
intercellular communication. Only a limited number of proteins have been identified from the …

Abstract Foxa2 (HNF3β) is a one of three, closely related transcription factors that are critical
to the development and function of the mouse liver. We have used chromatin …