Neutrophils are the major circulating white blood cells in humans. They play an essential
role in host defense against pathogens. In healthy individuals, circulating neutrophils are in …

Neutrophils are key cells of innate immunity and during inflammation. Upon activation, they
produce large amounts of superoxide anion (O2−.) and ensuing reactive oxygen species …

Immune system dysfunction is paramount in coronavirus disease 2019 (COVID-19) severity
and fatality rate. Mucosal-associated invariant T (MAIT) cells are innate-like T cells involved …

Objective. The aetiology of SAPHO (synovitis, acne, palmoplantar pustulosis, hyperostosis,
osteitis) syndrome seems to involve genetic, infectious and immunological components. We …

Anaphylaxis is a systemic acute hypersensitivity reaction that is considered to depend on
allergen-specific immunoglobulin E (IgE) antibodies and histamine release by mast cells …

Objective: The mechanisms linking severe inflammation and coagulation during heatstroke
are poorly understood. Here, we examined the roles of the tissue factor pathway, leukocyte …

Reactive oxygen species (ROS) production by the neutrophil NADPH oxidase plays a key
role in host defense against pathogens, such as bacteria and fungi. Zymosan a cell-wall …

Reactive oxygen species (ROS) are produced by numerous biological systems and by
several phagocytes such as neutrophils and macrophages. ROS include mostly superoxide …

Chronic granulomatous disease (CGD) is a primary immunodeficiency caused by failure of
superoxide production in phagocytic cells. The disease is characterised by recurrent …

Mouse bone marrow erythropoiesis is homeostatic, whereas after acute anemia, bone
morphogenetic protein 4 (BMP4)–dependent stress erythropoiesis develops in the spleen …