Extraordinary technical advances in the field of human genetics over the past few years
have catalyzed an explosion of new information about the genetics of human autoimmunity …

For a long time, reactive oxygen species (ROS) produced by the phagocyte NADPH oxidase
(NOX2) complex have been considered harmful mediators of inflammation owing to their …

Autoimmune diseases such as rheumatoid arthritis (RA) are chronic diseases that cannot be
prevented or cured. If the pathologic basis of such diseases would be known, it might be …

The current review on the function of neutrophil cytosolic factor 1 (NCF1) and induced
reactive oxygen species (ROS) is based on a genetic search for the major genes controlling …

Objective. The severity of joint destruction in rheumatoid arthritis (RA) is highly variable from
patient to patient and is influenced by genetic factors. Genome-wide association studies …

Objectives Ncf1 polymorphisms leading to low production of reactive oxygen species (ROS)
are strongly associated with autoimmune diseases in animal models. The human NCF1 …

Aims: The aim of this study was to investigate genetic variants in the gene neutrophil
cytosolic factor 1 (NCF1) for association with rheumatoid arthritis (RA). In rodent models, a …

Rheumatoid arthritis (RA) is a chronic inflammatory disease with a heritability of 60%.
Genetic contributions to RA are made by multiple genes, but only a few gene associations …

A single nucleotide polymorphism in Ncf1 has been found with a major effect on chronic
inflammatory autoimmune diseases in the rat with the surprising observation that a lower …

Significance: An unexpected finding, revealed by positional cloning of genetic
polymorphisms controlling models for rheumatoid arthritis, exposed a new function of Ncf 1 …