Publisher Summary This chapter reviews the role of cytokines in the pathogenesis of sepsis.
The various models for sepsis are also discussed, including the human models and animal …

Dealing with immunogenicity of biologicals: assessment and c... : Current Opinion in
Rheumatology Dealing with immunogenicity of biologicals: assessment and clinical relevance …

To date, millions of people have been treated with therapeutic monoclonal antibodies
(TmAbs) for various indications. It is becoming increasingly clear that TmAbs can be …

Oncogene-induced cellular senescence (OIS) is emerging as a potent cancer-protective
response to oncogenic events, serving to eliminate early neoplastic cells from the …

Abstract Interleukin-6 (IL-6) is likely to be an important mediator of the inflammatory
response. We measured levels of this cytokine in plasma samples from 37 patients with …

Antibodies play a central role in immunity by forming an interface with the innate immune
system and, typically, mediate proinflammatory activity. We describe a novel …

Human mononuclear leukocytes produce a growth factor (HGF) for hybridoma and
plasmacytoma cells. HGF has recently been proven to be identical to IFN‐β2, 26‐kDa …

Endotoxemia was evoked by bolus injection of Escherichia coli endotoxin (2 ng/kg body
weight) in six healthy subjects to investigate the early kinetics of cytokine release in relation …

During human immunodeficiency virus infection and allergic diseases, characterized by a
dominant T helper (Th) 2 response, overproduction of prostaglandin E2 (PGE2) is observed …

Context Short-term data on the immunogenicity of monoclonal antibodies showed
associations between the development of antidrug antibodies and diminished serum drug …