Clinical pharmacokinetics of metformin
Metformin is widely used for the treatment of type 2 diabetes mellitus. It is a biguanide
developed from galegine, a guanidine derivative found in Galega officinalis (French lilac) …
developed from galegine, a guanidine derivative found in Galega officinalis (French lilac) …
Clinical pharmacokinetics and pharmacodynamics of celecoxib: a selective cyclo-oxygenase-2 inhibitor
Celecoxib, a nonsteroidal anti-inflammatory drug (NSAID), is the first specific inhibitor of
cyclo-oxygenase-2 (COX-2) approved to treat patients with rheumatism and osteoarthritis …
cyclo-oxygenase-2 (COX-2) approved to treat patients with rheumatism and osteoarthritis …
A benefit-risk assessment of benzbromarone in the treatment of gout: was its withdrawal from the market in the best interest of patients?
Benzbromarone, a potent uricosuric drug, was introduced in the 1970s and was viewed as
having few associated serious adverse reactions. It was registered in about 20 countries …
having few associated serious adverse reactions. It was registered in about 20 countries …
Effect of St John's wort and ginseng on the pharmacokinetics and pharmacodynamics of warfarin in healthy subjects
X Jiang, KM Williams, WS Liauw… - British journal of …, 2004 - Wiley Online Library
Aim The aim of this study was to investigate the effect of St John's wort and ginseng on the
pharmacokinetics and pharmacodynamics of warfarin. Methods This was an open‐label …
pharmacokinetics and pharmacodynamics of warfarin. Methods This was an open‐label …
Effect of ginkgo and ginger on the pharmacokinetics and pharmacodynamics of warfarin in healthy subjects
X Jiang, KM Williams, WS Liauw… - British journal of …, 2005 - Wiley Online Library
Aim The aim of this study was to investigate the effect of two common herbal medicines,
ginkgo and ginger, on the pharmacokinetics and pharmacodynamics of warfarin and the …
ginkgo and ginger, on the pharmacokinetics and pharmacodynamics of warfarin and the …
Allopurinol hypersensitivity: a systematic review of all published cases, 1950–2012
SN Ramasamy, CS Korb-Wells, DRW Kannangara… - Drug safety, 2013 - Springer
Background Allopurinol is the primary therapy for the management of chronic gout.
Utilization of allopurinol has increased in tandem with the growing prevalence of gout …
Utilization of allopurinol has increased in tandem with the growing prevalence of gout …
Clinical pharmacokinetics and pharmacodynamics of allopurinol and oxypurinol
Allopurinol is the drug most widely used to lower the blood concentrations of urate and,
therefore, to decrease the number of repeated attacks of gout. Allopurinol is rapidly and …
therefore, to decrease the number of repeated attacks of gout. Allopurinol is rapidly and …
Insights into the poor prognosis of allopurinol-induced severe cutaneous adverse reactions: the impact of renal insufficiency, high plasma levels of oxypurinol and …
WH Chung, WC Chang, SL Stocker, CG Juo… - Annals of the …, 2015 - ard.bmj.com
Objective Allopurinol, an antihyperuricaemic agent, is one of the common causes of life-
threatening severe cutaneous adverse reactions (SCAR), including drug rash with …
threatening severe cutaneous adverse reactions (SCAR), including drug rash with …
Pharmacodynamic interaction of warfarin with cranberry but not with garlic in healthy subjects
MI Mohammed Abdul, X Jiang… - British journal of …, 2008 - Wiley Online Library
Background and purpose: Patients commonly take complementary medicines in conjunction
with warfarin yet evidence supporting the safety or the risk of a herb–drug interaction is …
with warfarin yet evidence supporting the safety or the risk of a herb–drug interaction is …
Population pharmacokinetics of metformin in healthy subjects and patients with type 2 diabetes mellitus: simulation of doses according to renal function
Abstract Background and Objective Metformin is contraindicated in patients with renal
impairment; however, there is poor adherence to current dosing guidelines. In addition, the …
impairment; however, there is poor adherence to current dosing guidelines. In addition, the …