User profiles for "author:Jean-Pierre David"
Jean Pierre DavidProfesseur en génie électrique, Polytechnique Montréal Verified email at polymtl.ca Cited by 5582 |
The multiple faces of autoimmune-mediated bone loss
G Schett, JP David - Nature Reviews Endocrinology, 2010 - nature.com
Inflammation perturbs normal bone homeostasis and is known to induce bone loss, as it
promotes both local cartilage degradation and local and systemic bone destruction by …
promotes both local cartilage degradation and local and systemic bone destruction by …
Binaryconnect: Training deep neural networks with binary weights during propagations
M Courbariaux, Y Bengio… - Advances in neural …, 2015 - proceedings.neurips.cc
Abstract Deep Neural Networks (DNN) have achieved state-of-the-art results in a wide range
of tasks, with the best results obtained with large training sets and large models. In the past …
of tasks, with the best results obtained with large training sets and large models. In the past …
The role of Wnt proteins in arthritis
G Schett, J Zwerina, JP David - Nature clinical practice Rheumatology, 2008 - nature.com
Wnt proteins regulate organ development, tumorigenesis and bone homeostasis, among
other functions. The binding of Wnt proteins to plasma membrane receptors on …
other functions. The binding of Wnt proteins to plasma membrane receptors on …
[HTML][HTML] Osteoclasts are essential for TNF-α–mediated joint destruction
K Redlich, S Hayer, R Ricci, JP David… - The Journal of …, 2002 - Am Soc Clin Investig
The detailed cellular and molecular mechanisms leading to joint destruction in rheumatoid
arthritis, a disease driven by proinflammatory cytokines, are still unknown. To address the …
arthritis, a disease driven by proinflammatory cytokines, are still unknown. To address the …
Training deep neural networks with low precision multiplications
Multipliers are the most space and power-hungry arithmetic operators of the digital
implementation of deep neural networks. We train a set of state-of-the-art neural networks …
implementation of deep neural networks. We train a set of state-of-the-art neural networks …
[HTML][HTML] Liver tumor development: c-Jun antagonizes the proapoptotic activity of p53
The transcription factor c-Jun mediates several cellular processes, including proliferation
and survival, and is upregulated in many carcinomas. Liver-specific inactivation of c-Jun at …
and survival, and is upregulated in many carcinomas. Liver-specific inactivation of c-Jun at …
[PDF][PDF] Glucocorticoids suppress bone formation by attenuating osteoblast differentiation via the monomeric glucocorticoid receptor
A Rauch, S Seitz, U Baschant, AF Schilling, A Illing… - Cell metabolism, 2010 - cell.com
Development of osteoporosis severely complicates long-term glucocorticoid (GC) therapy.
Using a Cre-transgenic mouse line, we now demonstrate that GCs are unable to repress …
Using a Cre-transgenic mouse line, we now demonstrate that GCs are unable to repress …
JNK1 modulates osteoclastogenesis through both c-Jun phosphorylation-dependent and-independent mechanisms
JP David, K Sabapathy, O Hoffmann… - Journal of cell …, 2002 - journals.biologists.com
Phosphorylation of the N-terminal domain of Jun by the Jun kinases (JNKs) modulates the
transcriptional activity of AP-1, a dimeric transcription factor typically composed of c-Jun and …
transcriptional activity of AP-1, a dimeric transcription factor typically composed of c-Jun and …
[PDF][PDF] Cutaneous Na+ storage strengthens the antimicrobial barrier function of the skin and boosts macrophage-driven host defense
J Jantsch, V Schatz, D Friedrich, A Schröder, C Kopp… - Cell metabolism, 2015 - cell.com
Immune cells regulate a hypertonic microenvironment in the skin; however, the biological
advantage of increased skin Na+ concentrations is unknown. We found that Na+ …
advantage of increased skin Na+ concentrations is unknown. We found that Na+ …
[HTML][HTML] Impaired postnatal hepatocyte proliferation and liver regeneration in mice lacking c‐jun in the liver
A Behrens, M Sibilia, JP David… - The EMBO …, 2002 - embopress.org
Mice lacking the AP‐1 transcription factor c‐jun die at mid‐gestation showing heart defects
and impaired hepatogenesis. To inactivate c‐jun in hepatocytes, mice carrying a floxed c …
and impaired hepatogenesis. To inactivate c‐jun in hepatocytes, mice carrying a floxed c …