Prostaglandins are likely to play an important role in the physiologic and pathologic
responses of skeletal tissue. They are potent agonists that can stimulate and inhibit bone …

Osteoarthritis (OA), one of the most common skeletal disorders characterized by cartilage
degradation and osteophyte formation in joints, is induced by accumulated mechanical …

A defect in Klotho gene expression in mice accelerates the degeneration of multiple age-
sensitive traits. Here, we show that overexpression of Klotho in mice extends life span …

A new gene, termed klotho, has been identified that is involved in the suppression of several
ageing phenotypes. A defect in klotho gene expression in the mouse results in a syndrome …

It is now widely accepted that skin sensitivity will be very important for future robots used by
humans in daily life for housekeeping and entertainment purposes. Despite this fact …

Skin-like sensitivity, or the capability to recognize tactile information, will be an essential
feature of future generations of robots, enabling them to operate in unstructured …

This study aimed to estimate the prevalence of locomotive syndrome, sarcopenia, and frailty
and clarify their co-existence in a population-based cohort. The third survey of Research on …

As locally converted estrogen from testicular testosterone contributes to apparent androgen
activity, the physiological significance of androgen receptor (AR) function in the beneficial …

Based on the fact that aging is associated with a reciprocal decrease of osteogenesis and
an increase of adipogenesis in bone marrow and that osteoblasts and adipocytes share a …

Musculoskeletal diseases, especially osteoarthritis (OA) and osteoporosis (OP), impair
activities of daily life (ADL) and quality of life (QOL) in the elderly. Although preventive …