Common variable immunodeficiency (CVID) describes a heterogeneous subset of
hypogammaglobulinemias of unknown etiology. Typically, patients present with recurrent …

The consumption of immunoglobulins (Ig) is increasing due to better recognition of antibody
deficiencies, an aging population, and new indications. This review aims to examine the …

Autoimmune and immunodeficiency diseases are outcomes of a dysfunctional immune
system and represent 2 sides of the same coin. Multiple single-gene defects have been …

No genetic defect is known to cause common variable immunodeficiency (CVID), a
heterogeneous human disorder leading to adult-onset panhypogammaglobulinemia. In a …

The heterogeneity of common variable immunodeficiency (CVID) calls for a classification
addressing pathogenic mechanisms as well as clinical relevance. This European …

The functional interaction of BAFF and APRIL with TNF receptor superfamily members
BAFFR, TACI and BCMA is crucial for development and maintenance of humoral immunity in …

Objective Recurrent digital ulcers are a manifestation of vascular disease in patients with
systemic sclerosis (SSc; scleroderma) and lead to pain, impaired function, and tissue loss …

Splenectomized and asplenic patients have a high incidence of infections by encapsulated
bacteria and do not respond to polysaccharide vaccines. To understand whether the …

Hypogammaglobulinemia is the hallmark of common variable immunodeficiency (CVID)
syndrome, a heterogeneous disorder predisposing patients to recurrent bacterial infections …

B-cell survival depends on signals induced by B-cell activating factor (BAFF) binding to its
receptor (BAFF-R). In mice, mutations in BAFF or BAFF-R cause B-cell lymphopenia and …