Acute respiratory distress syndrome (ARDS), an inflammatory condition with high mortality
rates, is common in severe COVID-19, whose risk is reduced by metformin rather than other …

Group 2 Innate lymphoid cells (ILC2) contribute significantly to allergic inflammation.
However, the role of microbiota on ILC2s remains to be unraveled. Here we show that short …

The gut microbiome is a malleable microbial community that can remodel in response to
various factors, including diet, and contribute to the development of several chronic …

Background Allergic asthma is a prevalent inflammatory disease of the airways caused by
dysregulated immune balance in the lungs with incompletely understood pathogenesis. The …

The PTPN11 gene, encoding the tyrosine phosphatase SHP-2, is overexpressed in
rheumatoid arthritis (RA) fibroblast-like synoviocytes (FLS) compared with osteoarthritis (OA) …

There has been a global increase in rates of obesity with a parallel epidemic of non-
alcoholic fatty liver disease (NAFLD). Autophagy is an essential mechanism involved in the …

Objective In rheumatoid arthritis (RA), fibroblast-like synoviocytes (FLS) that line joint
synovial membranes aggressively invade the extracellular matrix, destroying cartilage and …

Background The impact of exposure to air pollutants, such as fine particulate matter (PM), on
the immune system and its consequences on pediatric asthma, are not well understood. We …

Objective During rheumatoid arthritis (RA), fibroblast‐like synoviocytes (FLS) critically
promote disease pathogenesis by aggressively invading the extracellular matrix of the joint …

TGF-β type III receptor (TβRIII) is a coreceptor for TGFβ family members required for high-
affinity binding of these ligands to their receptors, potentiating their cellular functions. TGF-β …