Autoantibodies are frequently observed in healthy individuals. In a minority of these
individuals, they lead to manifestation of autoimmune diseases, such as rheumatoid arthritis …

Regulatory T cells (Treg) are crucial for the maintenance of peripheral tolerance and for the
control of ongoing inflammation and autoimmunity. The cytokine interleukin-2 (IL-2) is …

An estimated 20–25% of the population is affected by chronic, non-communicable
inflammatory skin diseases. Chronic skin inflammation has many causes. Among the most …

Objective The 1980 American College of Rheumatology (ACR) classification criteria for
systemic sclerosis (SSc) lack sensitivity for early SSc and limited cutaneous SSc. The …

Objectives To determine the causes and predictors of mortality in systemic sclerosis (SSc).
Methods Patients with SSc (n= 5860) fulfilling the American College of Rheumatology …

The aim was to update the 2009 European League against Rheumatism (EULAR)
recommendations for the treatment of systemic sclerosis (SSc), with attention to new …

Background A phase 2 trial of tocilizumab showed preliminary evidence of efficacy in
systemic sclerosis. We assessed skin fibrosis and systemic sclerosis-associated interstitial …

Background Systemic sclerosis (SSc) features autoimmunity, vasculopathy and tissue
fibrosis. The renin-angiotensin and endothelin systems have been implicated in …

Background Systemic sclerosis is a rare disabling autoimmune disease with few treatment
options. The efficacy and safety of tocilizumab, an interleukin 6 receptor-α inhibitor, was …

Objective. The 1980 American College of Rheuma-tology (ACR) classification criteria for
systemic sclerosis (SSc) lack sensitivity for early SSc and limited cutaneous SSc. The …