The JAK-STAT pathway: impact on human disease and therapeutic intervention
JJ O'Shea, DM Schwartz, AV Villarino… - Annual review of …, 2015 - annualreviews.org
The Janus kinase (JAK)–signal transducer of activators of transcription (STAT) pathway is
now recognized as an evolutionarily conserved signaling pathway employed by diverse …
now recognized as an evolutionarily conserved signaling pathway employed by diverse …
JAK inhibition as a therapeutic strategy for immune and inflammatory diseases
DM Schwartz, Y Kanno, A Villarino, M Ward… - Nature reviews Drug …, 2017 - nature.com
The discovery of cytokines as key drivers of immune-mediated diseases has spurred efforts
to target their associated signalling pathways. Janus kinases (JAKs) are essential signalling …
to target their associated signalling pathways. Janus kinases (JAKs) are essential signalling …
[HTML][HTML] JAK–STAT signaling as a target for inflammatory and autoimmune diseases: current and future prospects
The Janus kinase/signal transduction and activator of transcription (JAK–STAT) signaling
pathway is implicated in the pathogenesis of inflammatory and autoimmune diseases …
pathway is implicated in the pathogenesis of inflammatory and autoimmune diseases …
Type I/II cytokines, JAKs, and new strategies for treating autoimmune diseases
Cytokines are major drivers of autoimmunity, and biologic agents targeting cytokines have
revolutionized the treatment of immune-mediated diseases. Despite the effectiveness of …
revolutionized the treatment of immune-mediated diseases. Despite the effectiveness of …
Loss-of-function mutations in TNFAIP3 leading to A20 haploinsufficiency cause an early-onset autoinflammatory disease
Q Zhou, H Wang, DM Schwartz, M Stoffels, YH Park… - Nature …, 2016 - nature.com
Systemic autoinflammatory diseases are driven by abnormal activation of innate immunity.
Herein we describe a new disease caused by high-penetrance heterozygous germline …
Herein we describe a new disease caused by high-penetrance heterozygous germline …
[HTML][HTML] Autocrine vitamin D signaling switches off pro-inflammatory programs of TH1 cells
The molecular mechanisms governing orderly shutdown and retraction of CD4+ type 1
helper T (TH1) cell responses remain poorly understood. Here we show that complement …
helper T (TH1) cell responses remain poorly understood. Here we show that complement …
[HTML][HTML] Variant STAT4 and Response to Ruxolitinib in an Autoinflammatory Syndrome
H Baghdassarian, SA Blackstone… - … England Journal of …, 2023 - Mass Medical Soc
Background Disabling pansclerotic morphea (DPM) is a rare systemic inflammatory
disorder, characterized by poor wound healing, fibrosis, cytopenias …
disorder, characterized by poor wound healing, fibrosis, cytopenias …
[HTML][HTML] Adaptive immune responses to SARS-CoV-2 persist in the pharyngeal lymphoid tissue of children
Most studies of adaptive immunity to SARS-CoV-2 infection focus on peripheral blood, which
may not fully reflect immune responses at the site of infection. Using samples from 110 …
may not fully reflect immune responses at the site of infection. Using samples from 110 …
A20 haploinsufficiency (HA20): clinical phenotypes and disease course of patients with a newly recognised NF-kB-mediated autoinflammatory disease
FA Aeschlimann, ED Batu, SW Canna, E Go… - Annals of the …, 2018 - ard.bmj.com
Objectives The association between mutations in TNFAIP3, encoding the NF-kB regulatory
protein A20, and a new autoinflammatory disease has recently been recognised. This study …
protein A20, and a new autoinflammatory disease has recently been recognised. This study …
JAK-STAT signaling in human disease: From genetic syndromes to clinical inhibition
Since its discovery, the Janus kinase-signal transduction and activation of transcription (JAK-
STAT) pathway has become recognized as a central mediator of widespread and varied …
STAT) pathway has become recognized as a central mediator of widespread and varied …